منابع مشابه
Biosynthesis of cephalosporin C.
The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cy...
متن کاملIncorporation of acetate into cephalosporin C.
Cephalosporin C, an antibiotic with structure (I) (Abraham & Newton, 1961; Hodgkin & Maslen, 1961), was first isolated from an impure preparation of the chemically related penicillin NJ [(D-4amino-4-carboxybutyl)penicillin] that had been obtained from the culture fluid of a Cephalosporium sp. (Newton & Abraham, 1956; Abraham & Newton, 1956). The amount of cephalosporin C produced by this organi...
متن کاملThe X - Ray Analysis of Cephalosporin C
Bulow, C. & Seidel, F. (1924). Liebigs Ann. 439, 48. Cavallini, D., Frontali, N. & Toschi, G. (1949). Nature, Lond., 163, 568. De Ropp, R. S., Van Meter, J. C., De Renzo, E. C., McKerns, K. W., Pidacks, C., Bell, P. H., Ullman, E. F., Safir, S. R., Fanshawe, W. J. & Davis, S. B. (1958). J. Amer. chem. Soc. 80, 1004. Ellington, E. V., Hassall, C. H. & Plimmer, J. R. (1958). Chem. & Ind. p. 329. ...
متن کاملFormation of desacetylcephalosporin C in cephalosporin C fermentation.
The origin of desacetylcephalosporin C in cephalosporin C fermentation broths was investigated. Esterase activity was detected in cell-free extracts of Cephalosporium acremonium, but these extracts failed to deesterify cephalosporin C. When cephalosporin C was added to sterile and inoculated fermentation media, the antibiotic decayed at nearly identical rates. The formation of desacetylcephalos...
متن کاملProcess strategies for cephalosporin C fermentation
Cephalosporin C (CPC), a β-lactam antibiotic, is starting molecule for industrial production of semi synthetic cephalosporins. CPC fermentation has been carried out in Air Lift Reactor (indigenously made up of borosilicate glass) in different fermentation modes i.e., batch and fed batch modes using a mold Acremonium chrysogenum (synn. Cephalosporium acremonium). A definite correlation exists be...
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ژورنال
عنوان ژورنال: Journal of General Microbiology
سال: 1962
ISSN: 0022-1287
DOI: 10.1099/00221287-27-1-11